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  • D-dimer test: MedlinePlus Medical Encyclopedia

    2021-6-9 · Your health care provider may order a D-dimer test if you are showing symptoms of blood clots, such as: Swelling, pain, warmth, and changes in skin color of your leg; Sharp chest pain, trouble breathing, coughing up blood, and fast heart beat; Bleeding gums, nausea and vomiting, seizures, severe stomach and muscle pain, and decreased urine

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  • D-dimer - Understand the Test - Lab Tests Online

    2018-5-25 · D-dimer is one of the protein fragments produced when a blood clot gets dissolved in the body. It is normally undetectable or detectable at a very low level unless the body is forming and breaking down blood clots. Then, its level in the blood can significantly rise. This test detects D-dimer in the blood.

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  • D-Dimer Test For Blood Clots: Normal Range, Elevated

    2021-6-24 · A D-dimer test is a blood test that can be used to help rule out the presence of a serious blood clot. When you get a cut, your body takes a bunch of steps to make your blood clump up. It’s a ...

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  • Normal D-dimer levels do not exclude thrombotic ...

    Bilateral lower extremity duplex ultrasounds and d-dimer levels were performed within 36 hours of admission, day 3-4, day 7, and weekly until discharge. Results: Twenty-three patients were diagnosed with DVTs, with 18 DVTs detected within the first week of admission.

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  • Diagnostic accuracy of four different D-dimer assays:

    2021-5-1 · This YEARS algorithm differs from the Wells algorithm, in the way that a pre-test probability dependent D-dimer threshold is applied. Using the YEARS algorithm, patients with suspected PE are managed by simultaneous assessment of the YEARS clinical decision rule and measurement of D-dimer …

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  • Serum D-dimer should not be used in the diagnosis of ...

    2020-9-22 · serum D-dimer test was performed at 384days after sur- gery, and the previous TKR was not believed to be a relevant factor when the clinical suspicion leading to the

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  • Widely Used Types and Clinical Applications of D

    2016-3-25 · The i-CHROMA D-Dimer Test (SYCOmed e.K.) is a sandwich immunoassay with a nitrocellulose matrix designed for measuring plasma D-dimers within a working range of 50 to 10,000 ng per mL; the emitted fluorescence is measured with the i-CHROMA Reader. ... the patient length of stay decreased from 8.46 to 7.14 hours, and length of hospital ...

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  • Serum D-dimer should not be used in the diagnosis of ...

    2020-9-22 · The median age at the time of surgery was 70.41 years (range 53.34–86.01 years). Serum D-dimer was performed between 29 days and 266 days (median 60 days). Three patients were taking anticoagulants prior to surgery, 13 patients had a previous knee replacement, and five patients had a previous hip replacement.

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  • Trends and diagnostic value of D-dimer levels in

    2020-11-13 · ROC analyses were performed using hospitalization-wide D-dimer levels as well as subset analysis to examine D-dimer parameters within the first 7 days (maximum and rate of change), absolute and relative changes in D-dimer, and maximal consecutive rises in D-dimer. Statistical analyses were performed using SPSS (Ver. 25) and figures were generated using either SPSS and Graphpad Prism …

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  • Dimer - an overview | ScienceDirect Topics

    d-Dimer. d-Dimer is a plasmin-derived fibrin degradation product most commonly measured by a quantitative enzyme-linked immunosorbent assay (ELISA). d-Dimer testing is characterized as highly sensitive with a high negative predictive value useful in the exclusion of VTE, particularly in the outpatient or emergency department setting. With most assays, a level >500 ng/mL is considered abnormal.

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  • D-Dimer Testing to Determine the Duration of ...

    2019-5-17 · Second, d -dimer testing was performed 30 days after anticoagulation was discontinued. In a previous study, 8 we reported that only 15% of patients had an abnormal d -dimer level at the time of ...

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  • Normal D-dimer levels do not exclude thrombotic ...

    Recent studies report that a negative D-dimer test excludes thrombotic complications. We questioned the predictive value of a D-dimer test to exclude DVT and PE. Methods: Adult trauma patients admitted March 1999 to March 2001, with an Injury Severity Score > or =9 and expected length of stay >3 days, were approached for enrollment. Bilateral ...

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  • Diagnosis and Treatment of Venous

    2006-10-12 · D-dimer is a degradation product of a cross-linked fibrin blood clot. Levels of D-dimer are typically elevated in patients with acute venous thromboembolism, as well as in patients with a variety of nonthrombotic conditions (e.g., recent major surgery, hemorrhage, trauma, pregnancy or cancer).19 D-dimer assays are, in general, sensitive but ...

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  • Diagnosis and treatment of deep-vein thrombosis

    Michael P. Gruber, Todd M. Bull, in Clinical Respiratory Medicine (Third Edition), 2008 d-Dimer. d-Dimer is a plasmin-derived fibrin degradation product most commonly measured by a quantitative enzyme-linked immunosorbent assay (ELISA). d-Dimer testing is characterized as highly sensitive with a high negative predictive value useful in the exclusion of VTE, particularly in the outpatient or ...

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  • Dimer - an overview | ScienceDirect Topics

    2020-7-10 · COVID-19 [6]. However, the role of D-dimer in COVID-19 patients has not been fully investigated. In this study, we showed D-dimer levels in patient groups stratified by clinical severities, imaging staging, in-hospital death, and assessed the role of D-dimer as a biomarker for disease severity and clinical outcome. Methods Patients

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  • D-dimer as a biomarker for disease severity and mortality ...

    2019-6-12 · • The pre-test probability of DVT can be assessed using a clinical decision rule that stratifies DVT into “unlikely” or “likely”. If DVT is “unlikely”, refer for D-dimer test. If the D-dimer level is normal, DVT can be excluded; if the D-dimer level is increased, refer for compression ultrasound.

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  • Deep vein thrombosis: update on diagnosis and

    2021-1-19 · The AUC of D-dimer was 0.909 and the optimal probability cutoff was 2.025 mg/L at the last test (Fig. 2). The last D-dimer optimal cutoff value of 2.025 mg/L was more meaningful for the prognosis of survival or death, after comparing the AUCs and Youden indices of the two curves.

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  • The poor prognosis and influencing factors of high D

    2014-3-21 · D-DIMER DIMER B RT for 4 hrs whole blood IF DELAY >24HRS FREEZE PLASMA Daily DIGOXIN DIG T 2-8 C for 3 days. RT for 8 hrs. Remove serum from RBC's <2hrs Daily DILANTIN (PHENYTOIN) DIL T 2-8 C FOR 2 DAYS Remove serum from RBC's <2hrs Daily Chemistry tubes should be spun or submitted within 2 hours of collection.

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  • Test Stability Chart - d2xk4h2me8pjt2.cloudfront.net

    2021-4-23 · According to the results of the ROC analysis performed to predict in-hospital mortality, the D-dimer levels reached a 0.757 AUC value, and D-dimer levels above 292.5 ng/mL had a predictive odds ratio of 6.058. Other studies have also associated high D-dimer levels with high mortality.

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  • D-Dimer Testing to Determine the Duration of ...

    2019-5-17 · Second, d -dimer testing was performed 30 days after anticoagulation was discontinued. In a previous study, 8 we reported that only 15% of patients had an abnormal d -dimer level at the time of ...

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  • D-dimer as a biomarker for disease severity and mortality ...

    2020-7-10 · COVID-19 [6]. However, the role of D-dimer in COVID-19 patients has not been fully investigated. In this study, we showed D-dimer levels in patient groups stratified by clinical severities, imaging staging, in-hospital death, and assessed the role of D-dimer as a biomarker for disease severity and clinical outcome. Methods Patients

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  • Comparison of the Simplify D-dimer assay performed

    Background: The immunofiltration D-dimer assay could allow point-of-care testing for pulmonary embolism (PE). A study was undertaken to compare a clinician-performed qualitative D-dimer assay with the automated quantitative D-dimer test. Methods: A prospective observational study was conducted from January to October 2005 at an urban academic emergency department (ED). 1193 patients of mean ...

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  • The plasma D-dimer trends and their value in acute

    2021-5-17 · At least 10 repeated measurements of plasma D-dimer were performed in each case. Grouping. ... or adjust the location and length of the thrombolytic catheter. ... test accuracy of D-dimer …

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  • D-dimer as a biomarker for disease severity and

    2020-7-10 · The distributions of D-dimer levels among patients with different clinical staging, chest CT staging, and who survived and deceased during hospitalization are presented in Figs. 1, 2, 3, and 4.On admission, D-dimer levels significantly increased with increasing severity of COVID-19 as determined by clinical staging (Kendall’s tau-b = 0.374, P = 0.000), chest CT staging (Kendall’s tau-b = 0 ...

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  • Deep vein thrombosis - Diagnosis and treatment -

    2017-5-31 · D-dimer. The usefulness of D-dimer blood measurement is well established in diagnosis of venous thromboembolism in the non-pregnant population.20 However, a physiological gradual increase in circulating D-dimer occurs in pregnancy; hence its measurement may result in false positive findings.21 D-dimer measurements may be helpful in the diagnosis of DVT in early pregnancy as levels would be ...

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  • Diagnosis and management of deep vein thrombosis

    2021-6-2 · If the D-dimer test is positive, offer a proximal leg vein ultrasound scan with the results available within 4 hours if possible. If the results cannot be obtained within 4 hours: Offer interim therapeutic anticoagulation and a proximal leg vein ultrasound scan with the result available within 24 hours. If the D-dimer test is negative:

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  • Scenario: Management | Management | Deep vein

    Normality of data will be tested by the Kolmogorov-Smirnov test. One-way ANOVA will be used to compare the TBL, drainage volume, plasma D-dimer, PAI-1, TAT and F1+2 levels, maximum haemoglobin drop and LOS between groups. If there is a significant difference, the comparison between groups will be performed by Scheffe post hoc analysis test.

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  • D-dimer to guide the duration of anticoagulation in ...

    2014-7-10 · A total of 1057 patients (43.0% of the screened population) were eligible. Forty-seven (4.4%) patients were then excluded from the study because of consent withdrawal (16) or for conditions requiring continued anticoagulation (27), or they were lost to follow-up after the first D-dimer test (4).

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  • D-dimer testing for DVT is a game-changer in

    2018-5-31 · The D-dimer analyser is now being used successfully to assist with the assessment of patients presenting with suspected pulmonary embolism. It is hoped the effectiveness of this test to reduce waiting times, reduce length of stay, support rapid diagnosis and improve patient flow will be the catalyst for further expansion of POCT on the ACU.

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  • British Thoracic Society guidelines for the

    2003-6-1 · Unlike previous latex tests {S11}, the MDA d-dimer test seems promising because, as well as having a specificity of 45%, a negative test excludes VTE in those with both intermediate and low clinical probability. 110 Other tests appear potentially useful. 83, 111– 113 The Medical Devices Agency is currently comparing 10 d-dimer assays in ...

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  • Comparison of high specificity with standard versions

    2021-5-7 · Background: D-dimer assays are sensitive but have poor specificity. False positive results lead to extra imaging and hospital admissions.Objectives: To make a pilot comparison of the diagnostic accuracy of the standard quantitative latex HemosIL D-dimer assay with a newer HemosIL D-dimer HS version designed to have improved specificity.Patients/Methods: Consecutive patients presenting from …

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  • Deep vein thrombosis: a clinical review

    2011-4-29 · D-dimer assays are highly sensitive (values up to 95%), but have poor specificity to prove VTE. The negative predictive value for patients with a negative D-dimer blood test is nearly 100%. Hence a negative value of D-dimer may safely rule out both DVT and PE.

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  • Wide-range ELISA Kit for D-Dimer (D2D) | WEA506Mu

    Test Method Competitive Inhibition. Assay Length 3h. Detection Range 12.35-1,000ng/mL. Sensitivity The minimum detectable dose of this kit is typically less than 5.53ng/mL. Download Instruction Manual. UOM 48T 96T 96T*5 96T*10 96T*100. FOB. US 383. For more details, please contact local distributors!

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  • Dynamic changes of D-dimer and neutrophil

    2020-7-3 · Dynamic changes of D-dimer, NLR and other laboratory tests. The associations between dynamic changes in D-Dimer, NLR and infection markers, cardiac injury index and hospitalization days were shown in Table 3.It could be found that there was a strong correlation between D-Dimer, NLR and other markers (P < 0.05).The test showed a stronger correlation between hospitalization days, PCT and peak D ...

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  • COVID-19: Anticoagulation Recommended Even After

    2020-4-30 · Elevated D-dimer more than twice the upper limit of normal was also suggested as a high-risk group to get post-discharge extended prophylaxis, although without full consensus from the writing ...

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  • Prognostic value of thrombin generation parameters

    2021-4-8 · Square root transformation of ETP and D-dimer and logarithmic transformation of D-dimer/ETP ratio were performed for predictive analysis. 95% confidence interval and p …

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  • Dynamics of the full-length yeast Hsp90 dimer |

    2019-3-8 · The Hsp90 chaperone is a complex homodimeric biological assembly that assists in the folding of proteins. It can undergo global conformational changes between an open (Adenosindiphosphat, ADP-bound) and closed (Adenosintriphosphat, ATP-bound) state that are of functional importance. How the conformational transitions are triggered and coupled to chaperone function is not well understood.

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  • BTS GUIDELINES British Thoracic Society guidelines for

    D-dimer • Blood D-dimer assay should only be considered following assessment of clinical probability. [B] • D-dimer assay should not be performed in those with high clinical probability of PE. [B] • A negative D-dimer test reliably excludes PE in patients with low (SimpliRED, Vidas, MDA) or …

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  • Wide-range ELISA Kit for D-Dimer (D2D) | WEA506Mu

    Test Method Competitive Inhibition. Assay Length 3h. Detection Range 12.35-1,000ng/mL. Sensitivity The minimum detectable dose of this kit is typically less than 5.53ng/mL. Download Instruction Manual. UOM 48T 96T 96T*5 96T*10 96T*100. FOB. US 383. For more details, please contact local distributors!

    Get Price
  • British Thoracic Society guidelines for the

    2003-6-1 · Unlike previous latex tests {S11}, the MDA d-dimer test seems promising because, as well as having a specificity of 45%, a negative test excludes VTE in those with both intermediate and low clinical probability. 110 Other tests appear potentially useful. 83, 111– 113 The Medical Devices Agency is currently comparing 10 d-dimer assays in ...

    Get Price
  • Ultrasound for Lower Extremity Deep Venous

    2017-8-30 · D-dimer levels have been used in the diagnosis of a variety of thrombosis-related diseases. In this study, we evaluated whether measuring D-dimer levels can help to diagnose cerebral infarction (CI) in critically ill cancer patients. We retrospectively evaluated all cancer patients who underwent brain magnetic resonance imaging (MRI) between March 2010 and February 2014 at the medical oncology ...

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  • How Blood Clots Are Diagnosed - verywellhealth.com

    2020-7-3 · Dynamic changes of D-dimer, NLR and other laboratory tests. The associations between dynamic changes in D-Dimer, NLR and infection markers, cardiac injury index and hospitalization days were shown in Table 3.It could be found that there was a strong correlation between D-Dimer, NLR and other markers (P < 0.05).The test showed a stronger correlation between hospitalization days, PCT and peak D ...

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  • D-dimer levels and cerebral infarction in critically ill ...

    2020-6-8 · D-dimer was a routine coagulation test and the median level of this marker was significantly higher in the pregnant group compared with the nonpregnant group (2.5 μg/mL vs 0.3 μg/mL, P<0.001). No difference was observed in median platelet count between the two groups (189.0 × 10 9 /L vs 214.0 × 10 9 /L, P =0.238), which is also an indicator ...

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  • Dynamic changes of D-dimer and neutrophil

    1997-8-1 · Ten multiplex reactions were performed on a variety of genomic DNAs and a ‘no DNA’ control using tailed primers G1T1, G2T1, H1T1, H2T1, I1T1, I2T1, J1T1 and J2T1 at either 10 or 20 nM and the T1 Tag at 1 µM. The CF genotypes of the DNAs were ΔF508/ΔF508, ΔF508/W1282X, ΔF508/G542X, W1282X/+, G542X/+ and +/+.

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